Stoneman Syndrome

 

Stoneman syndrome or fibrodysplastic ossificans progressiva (FOP) or Munchmeyer's disease is a rare genetic disease of ectopic soft tissue calcification with hand and foot deformities leading to severe restriction of joint movements. It was first described in 1692 in a young patient who turned into wood. It may be sporadic or autosomal dominant. The disease is caused by mutation in the bone morphogenic protein (BMP) type I (Activin A receptor, type I [ACVR1]) leading to dysregulated bone formation.The incidence, as reported from Europe and United States, is around 1 in two million individuals.